INCREASED DENTAL IMPLANT OSTEOINTEGRATION IN MENOPAUSAL OSTEOPOROSIS IN WOMEN
Abstract
Introduction
Osteoporosis is a systemic skeletal disease that is accompanied by a decrease in
bone density and changes in bone microarchitecture, leading to increased fragility and
a high risk of fractures[1][2]. According to WHO data, approximately every third
woman and every fifth man over 50 suffers from osteoporosis[1][3]. In Russia, the
prevalence of osteoporosis among women after 50 years is ~33.8%, among men -
~26.9%[1]; the number of diagnosed patients is close to 14 million people[4][3]. In
postmenopause in women, calcium leaching from bones accelerates, which is
especially relevant for dental implantation: insufficient bone volume of the alveolar
ridge can limit the possibility of full-fledged osteointegrative implantation. On the
other hand, dental implants are successfully implanted in patients with osteoporosis.
Recent publications indicate high survival rates of implants (>90-95%) even in women
with osteoporosis[6][7]. Due to the increasing number of elderly patients and the
prevalence of osteoporosis, the task of ensuring reliable osseointegration during
menopause in women is becoming increasingly important both in maxillofacial surgery
and in dental practice. The purpose of this work is to summarize modern data on the
impact of osteoporosis (including drug-induced osteoporosis when taking
bisphosphonates) on the osteointegration of dental implants in women during the
climacteric period and to examine modern approaches (PRGF, osteoplasty, 3D-
planning) to treating such patients.
References
List of Literature (Alphabetical, GOST) :
1. Cho J.M., Lee S.J. Clinical outcomes and bone marker changes in postmenopausal
women with dental implants: a one-year prospective study // Int. J. Implant Dent.
2025. Vol.11. Art.41.
2. Giro G., Chambrone L., Goldstein A., et al. Impact of osteoporosis in dental
implants: A systematic review // World J. Orthop. 2015. Vol.6, No2. P.311-315.
3. Holahan C.M., Koka S., Kennel K.A., et al. Effect of osteoporotic status on the
survival of titanium dental implants // Int. J. Oral Maxillofac. Implants. 2008.
Vol.23, No5. P.905-910.
4. Khesin R.A., Kozlova M.V., Malichenko S.B., Goncharov Y.I. The osteo-
remodeling process in the jaw bones of elderly patients // Russ. J. Stomatol. Vol.7,
No.4. P.47-51.
5. Lemos C.A.A., de Oliveira A.S., Faé D.S., et al. Do dental implants placed in
patients with osteoporosis have higher risks of failure and marginal bone loss
compared to healthy patients? A systematic review with meta-analysis // Clin. Oral
Investig. 2023. Vol.27, No6. P.2483-2493.
6. Madrid C., Sanz M. What effect do systematically administered bisphosphonates
have on oral implant therapy? A systematic review // Clin. Oral Implants Res. 2009.
Vol.20, Suppl.4. P.87-95.
7. Mozzati M., Arata V., Giacomello M., et al. Failure risk estimates after dental
implant placement associated with growth factor-rich plasma-Endoret in
osteoporotic women under bisphosphonate therapy // J. Craniofac. Surg. 2015.
Vol.26, No3. P.749-755.
8. Tarasenko S.V., Ershova A.M. Application of synthetic osteoplastic materials to
increase the parameters of the alveolar bone of the human body before dental
implantation // Stomatology (Moscow).. 2017. Vol.96, No2. P.70-74.
9. Temmerman A., Rasmusson L., Kübler A., et al. A prospective, controlled,
multicenter study to evaluate the clinical outcome of implant treatment in women
with osteoporosis/osteopenia: 5-year results // J. Dent. Res. 2019. Vol.98, No1.
P.84-90.
10. Tardivo D., Delgado-Ruiz R.A., Marchesan M., et al. Applications of Growth
Factors in Implant Dentistry // Curr. Issues Mol. Biol. 2025. Vol.47, No5. Art.317.
11. World Osteoporosis Day 20.10.2022 | GBUZ PCKB1GBUZ PCKB1
https://pkkb1.ru/vsemirnyj-den-borby-osteoporozom/The osteo-remodeling
process in the jaw bones of older patients
12. https://www.mediasphera.ru/issues/rossijskaya-stomatologiya/2014/4/292072-
64062015048
13. Clinical outcomes and bone marker changes in postmenopausal women with dental
implants: a one-year prospective study | International Journal of Implant Dentistry
| Full Text
14. https://journalimplantdent.springeropen.com/articles/10.1186/s40729-025-00628-
4 researchgate.net
15. https://www.researchgate.net/profile/STarasenko/publication/316258083_Syntheti
c_osteoplastic_materials_for_alveolar_bone_augmentation_before_dental_implan
tation/links/5df9523ca6fdcc283728dcbe/Synthetic-osteoplastic-materials-for-
alveolar-bone-augmentation-before-dental-implantation.pdf
16. Failure risk estimates after dental implant placement associated with growth factor-
rich plasma-Endoret in osteoporotic women under bisphosphonate therapy -
PubMed
17. https://pubmed.ncbi.nlm.nih.gov/25974785/Impact of osteoporosis in dental
implants: A systematic review
18. https://www.wjgnet.com/2218-5836/abstract/v6/i2/311.htm
19. (PDF) Do dental implants placed in patients with osteoporosis have higher risks of
failure and marginal bone loss compared to healthy patients? Systematic review
with meta-analysis
20. https://www.researchgate.net/publication/369974039_Do_dental_implants_placed
_in_patients_with_osteoporosis_have_higher_risks_of_failure_and_marginal_bon
e_loss_compared_to_those_in_healthy_patients_A_systematic_review_with_meta
-analysis
21. Effect of osteoporotic status on the survival of titanium dental implants – PubMed
22. https://pubmed.ncbi.nlm.nih.gov/19014161/Applications of Growth Factors in
Implant Dentistry
23. https://www.mdpi.com/1467-3045/47/5/317
24. A Prospective, Controlled, Multicenter Study to Evaluate the Clinical Outcome of
Implant Treatment in Women with Osteoporosis/Osteopenia: 5-Year Results –