CLINICAL-NEUROPHYSIOLOGICAL AND NEUROIMMUNOLOGICAL CHARACTERISTICS OF CHRONIC HEADACHE FORMS
Keywords:
Keywords: Chronic headache, migraine, neurophysiology, neuroimmunology, optimization, treatmentAbstract
Abstract
Chronic headache disorders, notably chronic migraine and tension-type
headaches, represent a growing neurological concern due to their refractory nature and
multidimensional pathophysiology. This research, grounded on a cohort of 315
patients, explores the interplay of neurophysiological and neuroimmunological factors,
analyzing EEG markers, heart rate variability (HRV), and cytokine levels including IL-
6, TNF-α, and IL-10. Our findings demonstrate distinct EEG profiles and elevated
inflammatory markers in chronic migraine cases, supporting the hypothesis of central
sensitization and immune dysregulation. Treatment optimization through multimodal
approaches, tailored to patients’ neurobiological and psychological profiles, yielded
significant reductions in attack frequency and improved quality of life.
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