OSHQOZON-ICHAK TRAKTI PATOLOGIYALARINING PARODONT YALLIG‘LANISH KASALLIKLARI PATOGENEZIGA TA’SIRI
Keywords:
Kalit so‘zlar: parodontit; oshqozon-ichak kasalliklari; disbioz; og‘iz–ichak o‘qi; yallig‘lanish; sitokinlar; mikrobiota; metabolik buzilishlar; logistik regressiya; xavf omillariAbstract
Annotatsiya
Tadqiqotning maqsadi – oshqozon-ichak traktining (O‘IT) patologiyalarining
parodont to‘qimalaridagi yallig‘lanish kasalliklari patogeneziga ta’sirini shartli
kliniko-laborator ma’lumotlar modeli asosida baholashdan iborat edi. Tadqiqotga jami
200 nafar bemor jalb etilgan bo‘lib, ular O‘IT patologiyasi mavjud (n=100) va mavjud
bo‘lmagan (n=100) guruhlarga ajratildi. Gastroezofageal reflyuks kasalligi, surunkali
gastrit, yallig‘lanishli ichak kasalliklari va pankreatit tashxisi qo‘yilgan bemorlarda
parodont og‘irlik indeksi (PD_index 4,3 ± 2,2 ga nisbatan 3,0 ± 1,4; p < 0,01),
interleykin-6 (IL-6, 12,2 ± 3,4 pg/ml ga nisbatan 6,8 ± 2,5 pg/ml; p < 0,001) va S-
reaktiv oqsil (CRP, 4,1 ± 1,7 mg/l ga nisbatan 2,9 ± 1,4 mg/l; p < 0,001) darajalari
yuqori qayd etildi. O‘IT patologiyasi og‘irligi bilan parodontit ifodalanish darajasi
o‘rtasida statistik jihatdan ahamiyatli korrelyatsiya aniqlangan (r ≈ 0,46; p < 0,001).
Ko‘p omilli logistik regressiya tahlili shuni ko‘rsatdiki, O‘IT patologiyasi mavjudligi
og‘ir parodontit uchun mustaqil xavf omili hisoblanadi (OR = 1,87; 95 % ISh 1,25–
2,80; p = 0,003).
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