MORPHOLOGICAL CHANGES IN CARDIAC TISSUE AFTER MECHANICAL TRAUMA UNDER GENERAL ANESTHESIA: AN EXPERIMENTAL ANALYSIS
Keywords:
Keywords: heart, morphological change, general anesthesia, N₂O, mechanical trauma, experiment.Abstract
Abstract
This experimental study investigated morphological changes in rat heart tissue
subjected to mechanical trauma under general anesthesia (nitrous oxide – N₂O).
According to histological analysis, dystrophic changes in cardiomyocytes, karyolysis,
cytolysis, focal necrosis, interstitial edema, venous congestion, and leukocytic
infiltration were identified. These structural changes may impair cardiac function and
are essential indicators for evaluating the effects of anesthesia. The study results are
significant for early detection and prevention of cardiac complications in clinical
practice.
References
References
1. Grebennikov V.A. Neuromuscular Monitoring. 2019.
2. Demidov V.I. Respiratory Distress and Endotoxemia. 2023.
3. Stanley F., Malamed D. Pharmacology of Local and General Anesthetics. 2017.
4. Madjidova Ya.N., Karimov D.S., et al. Oxidative Stress and Anesthetics. Tashkent
Medical Journal, 2023.
5. Abdurahmonova D.R., Alijonova M.A. Comparative Analysis of Propofol and
Sevoflurane in Children. Pediatrics and Anesthesiology, 2024; 4(1):731–741.
6. Lazaranko L.L., Erokhlina M.V. Fundamentals of Cardiovascular Morphology.
Minsk: MedUniver, 2024.
7. Kulikov O.A., Balashov V.P. Cardiac Morphology in Experimental Lung Injury.
Morphological News, 2020; 28(2):64–73.
8. Atashev A.R. Spinal-Epidural Anesthesia in Traumatology: Effectiveness of
Longocaine. Interpretation & Research, 2023.
9. Avdeev S.N., et al. New Clinical Guidelines for COPD: Cardiac Implications.
Therapeutic Archives, 2024; 96(3):292–297.
10. Aminova M.I., Yusupova Z.Kh. Modern Anesthetics: Classification and
Applications. Innovations in Medicine, 2024; 44(4):175–179.
11. Antropova G.A., Stepanova E.N. Analysis of Narcotic Analgesic Drug Assortment
in Regions. Novgorod Medical Bulletin, 2023; 4(133):599–610.
12. Abdukadirov A., et al. Inhalational Anesthesia with Low Gas Flow in Children.
Current Issues in Pediatrics, 2024; 1(2):13–15.
13. Bubonova M.G., Aronov D.M. COVID-19 and Cardiovascular Diseases: From
Epidemiology to Rehabilitation. Pulmonology, 2020; 30(5):688–699.
14. Laxin R.E., Jirnova E.A., et al. Morphological and Ultrasound Changes in Lungs
Under COVID-19. Intensive Therapy Journal, 2023; 3:82–96.
15. Azaryonok M.K., et al. Molecular Markers of Post-COVID Interstitial Fibrosis.
Vitebsk Medical Journal, 2024; 23(1):58–67.
