MANAGEMENT OF COVID-19 AND POST-COVID COMPLICATIONS
Keywords:
Key words:COVID-19, Long COVID, post-COVID syndrome, post-acute sequelae of SARS-CoV-2 (PASC), multidisciplinary management, rehabilitation, chronic fatigue, pulmonary complications, cardiovascular complicationsAbstract
Abstract: The COVID-19 pandemic continues to pose significant long-term
health challenges due to post-acute sequelae of SARS-CoV-2 infection, commonly
known as Long COVID or post-COVID condition. This review provides a
comprehensive overview of the current evidence on the management of acute COVID-
19 and its post-acute complications. It summarizes the pathophysiology, clinical
manifestations across multiple organ systems, risk factors, diagnostic approaches, and
evidence-based management strategies. A multidisciplinary, individualized approach
combining rehabilitation, psychological support, and symptomatic treatment remains
the cornerstone of care. Early vaccination, optimal acute-phase management, and
timely rehabilitation are key to reducing the burden of Long COVID. Despite growing
research, high-quality evidence for many therapeutic interventions is still limited,
highlighting the need for continued research and specialized care pathways
References
Main References:
1.Nalbandian A. et al. Nature Medicine (2021)
2.Aiyegbusi O.L. et al. (2021)
3.Zeraatkar D. et al. BMJ (2024)
4.CADTH Rapid Review
5.AlShamrani M. et al. (2025)