RO‘ZA TUTISHNING ORGANIZMGA TA’SIRI: AUTOFAGIYA VA HUJAYRAVIY YANGILANISH MEXANIZMLARI
Keywords:
Kalit so‘zlar: Ro‘za, autofagiya, hujayraviy yangilanish, metabolizm, energiya almashinuvi, hujayra stressi, regeneratsiya, sog‘liqni saqlashAbstract
Annotatsiya. Ushbu maqolada ro‘za tutishning inson organizmiga fiziologik va
molekulyar ta’siri, xususan autofagiya jarayoni orqali hujayraviy yangilanish
mexanizmlari tahlil qilinadi. Oziq moddalarning vaqtinchalik cheklanishi natijasida
organizmda metabolik qayta dasturlanish yuzaga kelib, energiya manbalari qayta
taqsimlanadi va hujayra ichki komponentlarining parchalanishi faollashadi.
Autofagiya jarayoni orqali eskirgan yoki shikastlangan organellalar va oqsillar yo‘q
qilinib, hujayra ichki muvozanati saqlanadi. Tadqiqotlar shuni ko‘rsatadiki, ro‘za
autofagik jarayonlarni rag‘batlantirib, metabolik sog‘liqni yaxshilash, yallig‘lanishni
kamaytirish va hujayraviy regeneratsiyani qo‘llab-quvvatlashda muhim ahamiyatga
ega. Shuningdek, ro‘za tutish organizmning stressga moslashuvini oshiradi va ayrim
kasalliklar, jumladan metabolik sindrom hamda neyrodegenerativ kasalliklar
rivojlanish xavfini kamaytirishi mumkin.
References
Foydalanilgan adabiyotlar:
1. Takeshige, K., Baba, M., Tsuboi, S., Noda, T., & Ohsumi, Y. (1992). Autophagy
in yeast demonstrated with proteinase-deficient mutants and conditions for its
induction. Journal of Cell Biology, 119(2), 301–311.
2. Mizushima, N., Yoshimori, T., & Levine, B. (2010). Methods in mammalian
autophagy research. Cell, 140(3), 313–326.
3. Levine, B., & Kroemer, G. (2008). Autophagy in the pathogenesis of disease.
Cell, 132(1), 27–42.
4. Klionsky, D. J. (2007). Autophagy: from phenomenology to molecular
understanding in less than a decade. Nature Reviews Molecular Cell Biology,
8(11), 931–937.
5. Longo, V. D., & Mattson, M. P. (2014). Fasting: molecular mechanisms and
clinical applications. Cell Metabolism, 19(2), 181–192.
6. de Cabo, R., & Mattson, M. P. (2019). Effects of intermittent fasting on health,
aging, and disease. New England Journal of Medicine, 381(26), 2541–2551.
7. Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015). Essential
role for autophagy in life span extension. Journal of Clinical Investigation,
125(1), 85–93.
8. Rubinsztein, D. C., Marino, G., & Kroemer, G. (2011). Autophagy and aging.
Cell, 146(5), 682–695.
9. Anton, S. D., Moehl, K., Donahoo, W. T., et al. (2018). Flipping the metabolic
switch: understanding and applying the health benefits of fasting. Obesity, 26(2),
254–268.
