ЭПИЛЕПСИЯДА ЮРАК-ҚОН ТОМИР АСОРАТЛАРИ: УЧРАШ ЧАСТОТАСИ, ПАТОФИЗИОЛОГИК МЕХАНИЗМЛАРИ ВА ХУРУЖГА ҚАРШИ ДОРИЛАРИНИНГ РОЛИ

Authors

  • Ш.Б. Робиддинов Author
  • Р.Б. Азизова Author
  • Ч.А.Абдуллаева Author

Keywords:

Калит сўзлар: эпилепсия, эпилептик юрак, юрак-қон томир асоратлари, аритмия, юрак етишмовчилиги, автоном дисфункция, гипоксемия, хуружга қарши препаратлари.

Abstract

Аннотация 
 Эпилепсия нафақат марказий нерв тизими, балки юрак-қон томир тизими 
ҳолати билан ҳам боғлиқ комплекс клиник муаммодир. Популяцион ва клиник 
тадқиқотларда  эпилепсияли  беморларда  ишемик,  аритмик  ва  миокардиал 
асоратлар хавфи юқорилиги қайд этилган, бироқ ушбу боғлиқликнинг сабабий 
механизмлари ва индивидуал хавф омиллари тўлиқ аниқланмаган. 

References

АДАБИЁТЛАР

1. Fisher, R.S., et al., ILAE official report: a practical clinical definition of epilepsy.

Epilepsia, 2014. 55(4): p. 475-82.

2. Verrier, R.L. and S.C. Schachter, The Epileptic Heart Syndrome: Epidemiology,

pathophysiology and clinical detection. Epilepsy Behav Rep, 2024. 27: p. 100696.

3. Mayer, J., et al., Epilepsy and the risk of adverse cardiovascular events: A

nationwide cohort study. Eur J Neurol, 2024. 31(3): p. e16116.

4. Bucci, T., et al., Epilepsy-Heart Syndrome: Incidence and Clinical Outcomes of

Cardiac Complications in patients with Epilepsy. Curr Probl Cardiol, 2023.

48(10): p. 101868.

5. Chen, Z., D. Liew, and P. Kwan, Excess mortality and hospitalized morbidity in

newly treated epilepsy patients. Neurology, 2016. 87(7): p. 718-25.

6. Husein, N., C.B. Josephson, and M.R. Keezer, Understanding cardiovascular

disease in older adults with epilepsy. Epilepsia, 2021. 62(9): p. 2060-2071.

7. Wilson, D.A., et al., Myocardial infarction after epilepsy onset: A population-

based retrospective cohort study. Epilepsy Behav, 2018. 88: p. 181-188.

8. Cheng, C.Y., et al., Risk of Cardiac Morbidities and Sudden Death in Patients

With Epilepsy and No History of Cardiac Disease: A Population-Based

Nationwide Study. Mayo Clin Proc, 2021. 96(4): p. 964-974.

9. Doege, C., M. Luedde, and K. Kostev, Epilepsy is associated with an increased

incidence of heart failure diagnoses. Epilepsy Behav, 2021. 125: p. 108393.

10. Wang, J., et al., Epilepsy and long-term risk of arrhythmias. Eur Heart J, 2023.

44(35): p. 3374-3382.

11. Desai, R., et al., Burden of Arrhythmias in Epilepsy Patients: A Nationwide

Inpatient Analysis of 1.4 Million Hospitalizations in the United States. Cureus,

2017. 9(8): p. e1550.

12. Josephson, C.B., et al., Association of Enzyme-Inducing Antiseizure Drug Use

With Long-term Cardiovascular Disease. JAMA Neurol, 2021. 78(11): p. 1367-

1374.

13. Renoux, C., et al., Antiepileptic drugs and the risk of ischaemic stroke and

myocardial infarction: a population-based cohort study. BMJ Open, 2015. 5(8):

p. e008365.

14. Bardai, A., et al., Sudden cardiac death is associated both with epilepsy and with

use of antiepileptic medications. Heart, 2015. 101(1): p. 17-22.

15. Mayer, J., et al., Association of antiseizure medications and adverse

cardiovascular events: A global health federated network analysis. Epilepsia,

2024. 65(5): p. 1264-1274.

16. Volkers, N., Epilepsy and the heart: Intersecting pathways of neurologic and

cardiovascular risk. Epigraph, 2025. 27(2): p. 52-57.

17. Stefanidou, M., et al., Vascular risk factors as predictors of epilepsy in older age:

The Framingham Heart Study. Epilepsia, 2022. 63(1): p. 237-243.

18. Yu, C., X.J. Deng, and D. Xu, Gene mutations in comorbidity of epilepsy and

arrhythmia. J Neurol, 2023. 270(3): p. 1229-1248.

19. Mazzola, L., F. Mauguière, and F. Chouchou, Central control of cardiac activity

as assessed by intra-cerebral recordings and stimulations. Neurophysiol Clin,

2023. 53(2): p. 102849.

20. Lotufo, P.A., et al., A systematic review and meta-analysis of heart rate variability

in epilepsy and antiepileptic drugs. Epilepsia, 2012. 53(2): p. 272-82.

21. Nass, R.D., et al., Blood markers of cardiac stress after generalized convulsive

seizures. Epilepsia, 2019. 60(2): p. 201-210.

22. Rheims, S., et al., Hypoxemia following generalized convulsive seizures: Risk

factors and effect of oxygen therapy. Neurology, 2019. 92(3): p. e183-e193.

23. Powell, K.L., et al., Altered cardiac structure and function is related to seizure

frequency in a rat model of chronic acquired temporal lobe epilepsy. Neurobiol

Dis, 2021. 159: p. 105505.

24. Liu, Z., et al., Cardiac structural and molecular alterations in rodent models of

temporal lobe epilepsy. Epilepsia Open, 2025. 10(3): p. 809-821.

25. González, A., et al., Assessment of cardiac structure and function in a murine

model of temporal lobe epilepsy. Epilepsy Res, 2020. 161: p. 106300.

26. Fialho, G.L., et al., Maximal/exhaustive treadmill test features in patients with

temporal lobe epilepsy: Search for sudden unexpected death biomarkers. Epilepsy

Res, 2017. 133: p. 83-88.

27. Fialho, G.L., et al., Increased cardiac stiffness is associated with autonomic

dysfunction in patients with temporal lobe epilepsy. Epilepsia, 2018. 59(6): p.

e85-e90.

28. Pang, T.D., et al., Epileptic seizures and Epilepsy Monitoring Unit admission

disclose latent cardiac electrical instability. Epilepsy Behav, 2022. 135: p.

108881.

29. Mintzer, S., et al., Effects of antiepileptic drugs on lipids, homocysteine, and C-

reactive protein. Ann Neurol, 2009. 65(4): p. 448-56.

30. French, J.A., et al., FDA safety warning on the cardiac effects of lamotrigine: An

advisory from the Ad Hoc ILAE/AES Task Force. Epilepsia Open, 2021. 6(1): p.

45-48.

Published

2026-07-28

How to Cite

Ш.Б. Робиддинов, Р.Б. Азизова, & Ч.А.Абдуллаева. (2026). ЭПИЛЕПСИЯДА ЮРАК-ҚОН ТОМИР АСОРАТЛАРИ: УЧРАШ ЧАСТОТАСИ, ПАТОФИЗИОЛОГИК МЕХАНИЗМЛАРИ ВА ХУРУЖГА ҚАРШИ ДОРИЛАРИНИНГ РОЛИ . Ta’lim Innovatsiyasi Va Integratsiyasi, 74(1), 34-45. https://journalss.org/index.php/tal/article/view/36050