PREDICTION OF PREMATURE OVARIAN INSUFFICIENCY BASED ON SOME BIOCHEMICAL MARKERS
Keywords:
Key words: Premature ovarian insufficiency, biochemical markers, ovarian reserve, anti-Müllerian hormone, follicle-stimulating hormone, inhibin B, estradiol, prediction, reproductive endocrinology, early diagnosis.Abstract
Abstract: Premature ovarian insufficiency (POI), a major reproductive health concern for women under the age of forty, significantly influences fertility potential, hormonal balance, metabolic state, and quality of life. This condition is characterized by a reduction in both the quantity and quality of ovarian follicles long before natural menopause, resulting in diminished estrogen production, irregular menstrual cycles, and an early onset of menopausal symptoms. Contemporary advances in reproductive medicine and molecular biology have provided deep insights into the pathophysiological mechanisms underlying POI as well as the identification of critical biochemical markers that can assist in its early diagnosis and prediction. The reliability, reproducibility, and practicality of these biochemical markers are central to modern approaches in reproductive endocrinology, particularly as they allow clinicians to anticipate, counsel, and intervene in the disease process well before irreversible ovarian failure sets in.
References
1. Abdurashidova, S.R. (2018). "The significance of endocrine and biochemical parameters in ovarian insufficiency." Uzbekistan Medical Journal, 2(54), 32-36.
2. Ahmedova, N.S. (2019). "Anti-Müllerian hormone and other biochemical markers in women with premature ovarian failure." Andijan Medical Journal, 3(18), 25-29.
3. Akbarova, G.I., & Karimova, D.F. (2020). "Biochemical prognosis methods for premature ovarian insufficiency." Bulletin of Tashkent Medical Academy, 4(83), 41-45.
4. Djalilova, S.K. (2021). "Assessment of AMH and inhibin B in early diagnosis of ovarian insufficiency." Problems of Obstetrics and Gynecology, 1(63), 58-62.
5. Ergasheva, L.K., & Shodmonova, G.T. (2017). "Changes in lipid-related biochemical indices in ovarian insufficiency." Fergana Medical Journal, 2(27), 85-89.
6. Isroilova, D.T. (2022). "Diagnostic and predictive methods of premature ovarian failure in women." Medicine and Innovation, 2(5), 17-21.
7. Karimova, N.N. (2019). "Prediction of premature ovarian failure based on biochemical analyses." Scientific Research in Modern Medicine, 4(14), 90-93.
8. Saidova, Z.B., & Rakhimova, S.S. (2021). "Premature ovarian insufficiency and its biochemical basis in reproductive age women." Obstetrics and Gynecology, 3(74), 66-71.
