CLINICAL AND LABORATORY SIGNIFICANCE OF BRUCELLOSIS AND OPTIMIZATION OF TREATMENT
Keywords:
This study was conducted as a prospective observational clinical and laboratory investigation aimed at evaluating the clinical and laboratory significance of systemic inflammatory markers in patients with various forms of brucellosis. The research was carried out at a specialized infectious diseases hospital and outpatient departments over the period from 2022 to 2024. The study included 120 patients with confirmed brucellosis aged between 18 and 65 years.Abstract
Brucellosis is characterized by a polymorphic clinical course and a wide spectrum of manifestations, ranging from acute febrile illness to chronic debilitating forms with multisystem involvement. The causative agents, bacteria of the genus Brucella, are facultative intracellular pathogens capable of long-term persistence within macrophages and other cells of the reticuloendothelial system. This intracellular localization allows the pathogen to evade immune surveillance and contributes to chronic inflammation, relapses, and resistance to therapy. One of the key pathogenetic mechanisms of brucellosis is the development of a systemic inflammatory response.
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2025-12-20
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CLINICAL AND LABORATORY SIGNIFICANCE OF BRUCELLOSIS AND OPTIMIZATION OF TREATMENT. (2025). ZAMONAVIY TARAQQIYOT VA FAN: 21-ASR YONDASHUVLARI, 2(2), 73-75. https://journalss.org/index.php/zam/article/view/11825
