MOLECULAR MECHANIZMS OF DEVELOPMENT OF INFLAMMATORY REACTIONS IN BURNS
Keywords:
The further development of inflammatory reactions and infections in burns is associated with oxidants, which are formed to a greater extent in leukocytes than as a result of ischaemia and impaired perfusion of the affected tissues. The appearance of oxidants is also associated with the action of endotoxin, which is another initiator of inflammation. It appears in the circulation several days after the burn.Abstract
In burns, interleukin-6 is released, triggering the production of acute-phase proteins in the liver. Hypermetabolism ensues, and at the same time muscle tissue is rapidly broken down. In burn victims, serum IL-6 levels peak approximately one week after the burn, and this increase coincides with an increase in endotoxin levels. Very high plasma levels are observed in dying patients. IL-6 stimulates antibody production (T-cell factor or factor released by T-lymphocytes). It promotes the maturation of B cells into antibody-producing plasma cells.
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2025-11-20
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MOLECULAR MECHANIZMS OF DEVELOPMENT OF INFLAMMATORY REACTIONS IN BURNS. (2025). ZAMONAVIY TARAQQIYOT VA FAN: 21-ASR YONDASHUVLARI, 1(1), 101-102. https://journalss.org/index.php/zam/article/view/5898
